Hexane 99.99% HPLC Product identifier TRADE NAME: HEXANE 99.99% FOR HPLC & SPECTROSCOPY Details of the supplier of the safety data sheet Manufacturer/Supplier: RLS Chemicals 32 Main Reef Road Benrose, Johannesburg 2094 Emergency telephone number: Spill Tech: 086 100 0366 Emergency: 010 448 3426 1 Hexane 99.99% HPLC Identification · Classification of the substance or mixture H225 Highly flammable liquid and vapor. Toxic to Reproduction 2 H361 Suspected of damaging fertility or the unborn child. Specific Target Organ Toxicity – Repeated Exposure 2 H373 May cause damage to organs through prolonged or repeated exposure. Aspiration Hazard 1 Skin Irritation 2 Specific Target Organ Toxicity – Single Exposure 3 · Label elements H304 May be fatal if swallowed and enters airways. H315 Causes skin irritation. H336 May cause drowsiness or dizziness. · GHS label elements The substance is classified and labeled according to the Globally Harmonized System (GHS). (Contd. on page 2) 2 Hazard(s) identification * REACTIVITY 0 FIRE 3 HEALTH 1 · Hazard pictograms (Contd. of page 1) · Signal word Danger · Hazard statements Highly flammable liquid and vapor. Causes skin irritation. Suspected of damaging fertility or the unborn child. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure. May be fatal if swallowed and enters airways. · Precautionary statements Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. – No smoking. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapors/spray. Wash thoroughly after handling. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. If swallowed: Immediately call a poison center/doctor. Specific treatment (see on this label). Do NOT induce vomiting. If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove person to fresh air and keep comfortable for breathing. IF exposed or concerned: Get medical advice/attention. Call a poison center/doctor if you feel unwell. Get medical advice/attention if you feel unwell. Take off contaminated clothing and wash it before reuse. If skin irritation occurs: Get medical advice/attention. In case of fire: Use CO2, powder or water spray to extinguish. Store in a well-ventilated place. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. · Classification system: · NFPA ratings (scale 0 – 4) Health = 1 Fire = 3 · HMIS-ratings (scale 0 – 4) Health = 1 Fire = 3 Reactivity = 0 Reactivity = 0 Personal precautions, protective equipment and emergency procedures Wear protective equipment. Keep unprotected persons away. Environmental precautions: Do not allow to enter sewers/ surface or ground water. Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust). Dispose contaminated material as waste according to section 13. Ensure adequate ventilation. Reference to other sections See Section 7 for information on safe handling. See Section 8 for information on personal protection equipment. 6 Hexane 99.99% HPLC Accidental release measures · Other hazards · Results of PBT and vPvB assessment · PBT: Not applicable. · vPvB: Not applicable. Chemical characterization: Substances CAS: 110-54-3 Hexane < = 99.99% 3 Hexane 99.99% HPLC Composition/information on ingredients Description of first aid measures General information: Symptoms of poisoning may even occur after several hours; therefore medical observation for at least 48 hours after the accident. After inhalation: In case of unconsciousness place patient stably in side position for transportation. After skin contact: Immediately wash with water and soap and rinse thoroughly. After eye contact: Rinse opened eye for several minutes under running water. After swallowing: If symptoms persist consult doctor. Information for doctor: Most important symptoms and effects, both acute and delayed No further relevant information available. Indication of any immediate medical attention and special treatment needed No further relevant information available. 4 Hexane 99.99% HPLC First-aid measures Extinguishing media Suitable extinguishing agents: CO2, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. For safety reasons unsuitable extinguishing agents: Water with full jet Special hazards arising from the substance or mixture No further relevant information available. Advice for firefighters Protective equipment: No special measures required. 5 Hexane 99.99% HPLC Fire-fighting measures Additional information about design of technical systems: No further data; see section 7. Control parameters Additional information: The lists that were valid during the creation were used as basis. Exposure controls Personal protective equipment: General protective and hygienic measures: Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing. Wash hands before breaks and at the end of work. Store protective clothing separately. Avoid contact with the skin. Avoid contact with the eyes and skin. 8 Hexane 99.99% HPLC Exposure controls/personal protection · Components with limit values that require monitoring at the workplace: CAS: 110-54-3 Hexane PEL REL TLV Long-term value: 1800 mg/m³, 500 ppm Long-term value: 180 mg/m³, 50 ppm Long-term value: 50 ppm Skin; BEI · Ingredients with biological limit values: CAS: 110-54-3 Hexane BEI 0.5 mg/L LD50 Intraperitoneal: urine Time: end of shift LD50: 2.5-Hexanedione without hydrolysis (Contd. of page 3) See Section 13 for disposal information. · Protective Action Criteria for Chemicals · PAC-1: 260 ppm · PAC-2: 2900* ppm · PAC-3: 8600** ppm Handling: Precautions for safe handling No special precautions are necessary if used correctly. Information about protection against explosions and fires: Keep ignition sources away – Do not smoke. Protect against electrostatic charges. Conditions for safe storage, including any incompatibilities Storage: Requirements to be met by storerooms and receptacles: Store in a cool location. Information about storage in one common storage facility: Not required. Further information about storage conditions: Keep receptacle tightly sealed. Store in cool, dry conditions in well sealed receptacles. Specific end use(s) No further relevant information available. 7 Hexane 99.99% HPLC Handling and storage 9 Physical and chemical properties * · Information on basic physical and chemical properties · General Information · Appearance: Form: Liquid Color: Colorless · Odor: Sweetish · Odor threshold: Not determined. · pH-value: Not determined. · Change in condition Melting point/Melting range: Boiling point/Boiling range: -95 °C (-139 °F) 69 °C (156.2 °F) · Flash point: -26 °C (-14.8 °F) · Flammability (solid, gaseous): Highly flammable. · Auto igniting: 240 °C (464 °F) · Decomposition temperature: Not determined. · Ignition temperature: Not determined. · Danger of explosion: Product is not explosive. However, formation of explosive air/vapor mixtures are possible. · Explosion limits: Lower: 1.2 Vol % · Breathing equipment: In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air. · Protection of hands: The glove material has to be impermeable and resistant to the product/ the substance/ the preparation. Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation · Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. · Penetration time of glove material The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed. · Eye protection: · Body protection: Protective work clothing Toxicity Aquatic toxicity: No further relevant information available. Persistence and degradability No further relevant information available. Behavior in environmental systems: Bioaccumulative potential No further relevant information available. Mobility in soil No further relevant information available. 12 Ecological information Upper: 7.7 Vol % · Vapor pressure at 20 °C (68 °F): · Vapor pressure at 50 °C (122 °F): 160 hPa (120 mm Hg) 540 hPa (405 mm Hg) · Density at 20 °C (68 °F): · Relative density · Vapor density · Evaporation rate 0.659 g/cm³ (5.49936 lbs/gal) Not determined. Not determined. Not determined. · Solubility in / Miscibility with Water at 20 °C (68 °F): 0.1 g/l · Partition coefficient (n-octanol/water): Not determined. · Viscosity: Dynamic: Kinematic: Not determined. Not determined. · Other information No further relevant information available. * Reactivity No further relevant information available. Chemical stability Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications. Possibility of hazardous reactions No dangerous reactions known. Conditions to avoid No further relevant information available. Incompatible materials: No further relevant information available. Hazardous decomposition products: No dangerous decomposition products known. 10 Stability and reactivity Information on toxicological effects Acute toxicity: Primary irritant effect: on the skin: Irritant to skin and mucous membranes. on the eye: No irritating effect. Sensitization: No sensitizing effects known. Additional toxicological information: Carcinogenic categories IARC (International Agency for Research on Cancer) Substance is not listed. NTP (National Toxicology Program) Substance is not listed. OSHA-Ca (Occupational Safety & Health Administration) Substance is not listed. 11 Toxicological information 14 Transport information · UN-Number · DOT, IMDG, IATA UN1208 · UN proper shipping name · DOT · IMDG · IATA Hexanes HEXANES, MARINE POLLUTANT HEXANES · Transport hazard class(es) · DOT · Class 3 Flammable liquids · Label 3 · IMDG gx` · Class 3 Flammable liquids · Label 3 · IATA · Class 3 Flammable liquids · Additional ecological information: · General notes: Water hazard class 3 (Assessment by list): extremely hazardous for water Do not allow product to reach ground water, water course or sewage system, even in small quantities. Danger to drinking water if even extremely small quantities leak into the ground. · Results of PBT and vPvB assessment · PBT: Not applicable. · vPvB: Not applicable. · Other adverse effects No further relevant information available. Waste treatment methods Recommendation: Must not be disposed of together with household garbage. Do not allow product to reach sewage system. Uncleaned packagings: Recommendation: Disposal must be made according to official regulations. 13 Hexane 99.99% HPLC Disposal considerations Safety, health and environmental regulations/legislation specific for the substance or mixture No further relevant information available. Sara Section 355 (extremely hazardous substances): Substance is not listed. Section 313 (Specific toxic chemical listings): Substance is listed. TSCA (Toxic Substances Control Act): ACTIVE Hazardous Air Pollutants Substance is listed. Proposition 65 Chemicals known to cause cancer: Substance is not listed. Chemicals known to cause reproductive toxicity for females: Substance is not listed. Chemicals known to cause reproductive toxicity for males: Substance is listed. Chemicals known to cause developmental toxicity: Substance is not listed. Carcinogenic categories EPA (Environmental Protection Agency) II TLV (Threshold Limit Value) Substance is not listed. NIOSH-Ca (National Institute for Occupational Safety and Health) Substance is not listed. GHS label elements The substance is classified and labeled according to the Globally Harmonized System (GHS). (Contd. on page 9) 15 Regulatory information · Label 3 · Packing group · DOT, IMDG, IATA II · Environmental hazards: · Marine pollutant: Environmentally hazardous substance, liquid; Marine Pollutant No Symbol (fish and tree) · Special precautions for user Warning: Flammable liquids · Hazard identification number (Kemler code): 33 · EMS Number: F-E,S-D · Stowage Category E · Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code Not applicable. · Transport/Additional information: · DOT · Quantity limitations On passenger aircraft/rail: 5 L On cargo aircraft only: 60 L · Hazardous substance: 5000 lbs, 2270 kg · IMDG · Limited quantities (LQ) 1L · Excepted quantities (EQ) Code: E2 Maximum net quantity per inner packaging: 30 ml Maximum net quantity per outer packaging: 500 ml · UN “Model Regulation”: UN 1208 HEXANES, 3, II This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific product features and shall not establish a legally valid contractual relationship. · Department issuing SDS: Environment protection department. · Date of preparation / last revision · Creation date for SDS 15-08-2023. STN Revision 1.0, 28/01/2025: Reviewed SDS for accuracy. STN 16 Other information * · Hazard pictograms · Signal word Danger · Hazard statements Highly flammable liquid and vapor. Causes skin irritation. Suspected of damaging fertility or the unborn child. May cause drowsiness or dizziness. May cause damage to organs through prolonged or repeated exposure. May be fatal if swallowed and enters airways. · Precautionary statements Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. – No smoking. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapors/spray. Wash thoroughly after handling. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. If swallowed: Immediately call a poison center/doctor. Specific treatment (see on this label). Do NOT induce vomiting. If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove person to fresh air and keep comfortable for breathing. IF exposed or concerned: Get medical advice/attention. Call a poison center/doctor if you feel unwell. Get medical advice/attention if you feel unwell. Take off contaminated clothing and wash it before reuse. If skin irritation occurs: Get medical advice/attention. In case of fire: Use CO2, powder or water spray to extinguish. Store in a well-ventilated place. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. · Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
